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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K3
All Species:
26.67
Human Site:
S590
Identified Species:
53.33
UniProt:
Q99759
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99759
NP_002392.2
626
70898
S590
P
T
N
P
Q
L
P
S
H
I
S
E
H
G
R
Chimpanzee
Pan troglodytes
XP_001137191
630
70979
P595
P
T
N
P
K
L
P
P
H
V
S
D
Y
T
R
Rhesus Macaque
Macaca mulatta
XP_001116198
646
73052
S610
P
T
N
P
Q
L
P
S
H
I
S
E
H
G
R
Dog
Lupus familis
XP_537600
626
70813
S590
P
T
N
P
Q
L
P
S
H
I
S
E
H
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61084
626
70757
S590
P
T
N
P
Q
L
P
S
H
I
S
E
H
G
R
Rat
Rattus norvegicus
NP_001100528
626
70672
S590
P
T
N
P
Q
L
P
S
H
I
S
E
H
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520739
516
56869
I485
R
A
Q
R
T
L
T
I
F
M
E
Y
M
P
G
Chicken
Gallus gallus
XP_418076
653
73830
S617
P
T
N
P
Q
L
P
S
H
I
S
E
H
C
R
Frog
Xenopus laevis
NP_001089288
618
69717
D582
P
T
K
P
R
L
P
D
N
V
S
D
A
C
R
Zebra Danio
Brachydanio rerio
XP_688694
620
70271
S584
P
T
N
P
Q
L
P
S
H
I
S
E
H
T
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782621
389
43041
N358
S
V
S
Q
D
A
R
N
F
L
T
L
C
F
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23561
717
80702
W680
T
T
P
E
I
P
S
W
A
T
S
E
G
K
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
66
89.4
97.5
N.A.
96.6
96.3
N.A.
60.2
85.5
61
77.8
N.A.
N.A.
N.A.
N.A.
39.3
Protein Similarity:
100
78.5
90.8
99
N.A.
98.5
98.4
N.A.
65.5
90.9
74.5
85.9
N.A.
N.A.
N.A.
N.A.
48.5
P-Site Identity:
100
60
100
100
N.A.
100
100
N.A.
6.6
93.3
46.6
93.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
86.6
100
100
N.A.
100
100
N.A.
13.3
93.3
73.3
93.3
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
41.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
9
0
0
9
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
17
0
% C
% Asp:
0
0
0
0
9
0
0
9
0
0
0
17
0
0
0
% D
% Glu:
0
0
0
9
0
0
0
0
0
0
9
67
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
17
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
9
42
9
% G
% His:
0
0
0
0
0
0
0
0
67
0
0
0
59
0
0
% H
% Ile:
0
0
0
0
9
0
0
9
0
59
0
0
0
0
0
% I
% Lys:
0
0
9
0
9
0
0
0
0
0
0
0
0
9
9
% K
% Leu:
0
0
0
0
0
84
0
0
0
9
0
9
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
9
0
0
% M
% Asn:
0
0
67
0
0
0
0
9
9
0
0
0
0
0
9
% N
% Pro:
75
0
9
75
0
9
75
9
0
0
0
0
0
9
0
% P
% Gln:
0
0
9
9
59
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
0
9
9
0
9
0
0
0
0
0
0
0
75
% R
% Ser:
9
0
9
0
0
0
9
59
0
0
84
0
0
0
0
% S
% Thr:
9
84
0
0
9
0
9
0
0
9
9
0
0
17
0
% T
% Val:
0
9
0
0
0
0
0
0
0
17
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _